哮喘的临床

Mechanistic Insights From Bronchoscopy Airway Samples

具体地说, gene expression will be interrogated in single cells via 10x droplet-based RNA sequencing of airway brushings obtained from bronchoscopy. 的 gene expression data is used to characterize individuals cells as goblet c...

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的 Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)

的 primary outcome is the % change in mucus plug score from 1 week before treatment to 1 week post treatment.

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SPIROMICS Study of Early COPD Progression (SOURCE)

Parametric Response Mapping captures the change in lung density between matched inspiratory and expiratory images thereby enabling the distinction between normal lung parenchyma (PRMNORM), 肺气肿(PRMEMPH), 和non-emphysematou...

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Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology

We will compare change in EELV during the CPET (Cardiopulmonary Exercise Test) between the obese asthma patients with MD or without MD and between the patients with severe asthma with mucus plugs or without mucus plugs.

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Tissue Immune Interaction in Nasal Polyposis

This study enrolls chronic rhinosinusitis patients with and without nasal polyps. Investigators aim to compare the percentage of ILC2 and tuft cells present in nasal tissue and secretions between those who present with nasal polyp...

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Lung Function Outcomes Following Removal of Airway Mucus Plugs in 病人 With Asthma (FOCUS)

We will assess change from baseline FEV1 one week after and six months after removal of mucus plugs by bronchoscopy.

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PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study

Assessed prior to bronchodilator administration. Efficacy analyses will compare the end-of-period outcome values between test treatment and placebo.

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Blood Lymphocytes in Asthmatics Treated With 的rapeutic Proteins

的 investigators will compare lymphocyte counts in healthy controls to asthmatics on and off therapeutic proteins.

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CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment

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的 Effect of NAC on Lung Function and CT Mucus Score

的 primary outcome is the % change in FEV1 from the start to the end of each two-week treatment period (either placebo or 20% NAC).

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